Gene: [04^/PDE1A] phosphodiesterase 1A, calcium/calmodulin-dependent (61kD);


FUN

Cyclic nucleotide phosphodiesterases (PDEs), which degrade cyclic nucleotides to their corresponding monophosphates, play a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. PDEs have been divided into families based on substrate specificity, affinity, sensitivity to cofactors, and sensitivity to inhibitory drugs. Type I PDEs are activated by the binding of calmodulin in the presence of calcium."

FAG

The following genes coding for cyclic nucleotide phosphodiesterases have been found: GEM:04^/PDE1A; GEM:16p1311/PDE1B; GEM:00.0/PDE1C; GEM:00.0/PDE2A; GEM:00.0/PDE3A; GEM:11p15/PDE3B; GEM:19^/PDE4A; GEM:01p31/PDE4B; GEM:19^/PDE4C; GEM:05q12/PDE4D; GEM:05q3/PDE6A; GEM:04p163/PDE6B; GEM:10q24/PDE6C; GEM:17q25/PDE6G; GEM:12p13/PDE6H; GEM:00.0/PDE8A; GEM:00.0/PDE9A. See also GEM:04p1/CNGA1."

REF

CLO,SEQ "Loughney K &: JBC, 271, 796-806, 1996
LOC,CYG "Wilson DE, McKenna: AJHG, 43, A162, 1988

SWI

 SWISSPROT: P54750

KEY

mem, nucm, sign

CLA

coding, basic

LOC

04

MIM

 MIM: 171890

EZN

 ENZYME: 3.1.4.17